Bubble Up Pizza Casserole

Preheat Oven: Start by preheating your oven to 375°F (190°C). Grease a 9×13-inch baking dish with cooking spray and set aside.
Cook the Meat: In a large skillet over medium heat, cook the ground beef, onion, and garlic until the meat is browned and the onions are tender. Drain any excess fat.
Combine Ingredients: To the skillet, add the pizza sauce, Italian seasoning, garlic powder, salt, and pepper. Stir to combine everything evenly. Then, gently fold in the quartered biscuit dough pieces, making sure they are coated with the sauce mixture.
Layer in Baking Dish: Transfer half of the biscuit and meat mixture to the prepared baking dish. Sprinkle with half of the mozzarella and cheddar cheeses, and add a layer of pepperoni slices. Repeat the layers with the remaining biscuit mixture, cheese, and pepperoni.
Bake: Place the baking dish in the preheated oven and bake for about 25-30 minutes, or until the biscuits have puffed up and turned golden brown, and the cheese is bubbly.
Cool and Serve: Allow the casserole to cool for a few minutes before serving. This will make it easier to cut into portions and serve.